Genetic Variation

Genetic Variation

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Genetic Variation: A Laboratory Manualis the first compendium of protocols specifically geared towards genetic variation studies, and includes thorough discussions on their applications for human and model organism studies. Intended for graduate students and professional scientists in clinical and research settings, it covers the complete spectrum of genetic variationa€”from SNPs and microsatellites to more complex DNA alterations, including copy number variation. Written and edited by leading scientists in the field, the early sections of the manual are devoted to study design and generating genotype data, the use of resources such as HapMap and dbSNP, as well as experimental, statistical, and bioinformatic approaches for analyzing the data. The final sections include descriptions of genetic variation in model organisms and discussions of recent insights into human genetic ancestry, forensics, and human variation.A Laboratory Manual Michael P. Weiner, Stacey B. Gabriel, J. Claiborne Stephens ... of microsatellite markers first qualified as Mendelian by a plate of 30 triads, is about 5 x 10aquot; or 1 mutation per 2000 generations. This is consistent with two other studies that looked at a large number of microsatellites (Huang et al. ... As an example, microsatellite alleles can tag HLA extended haplotypes of intermediate frequency (Vorechovsky et al. ... Addition of just one microsatellite in 256 / Chapter 18.

Title:Genetic Variation
Author: Michael P. Weiner, Stacey B. Gabriel, J. Claiborne Stephens
Publisher: - 2007

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